Prophylatic treatment of migraine and migraine clinical variants with topiramate: an update
نویسندگان
چکیده
Migraine and migraine variants are common, chronic and incapacitating neurovascular disorders with a high impact on health resources. There is an extensive evidence base provided by double-blind, placebo-controlled trials showing that topiramate is a safe, effective and well tolerated drug in the management of migraine and its variants, being especially promising in the management of migraine-vertigo syndrome. Models both in the US and the UK have also shown that it offers a cost benefit when direct and indirect costs are evaluated, by reducing work loss, improving quality of life and reducing the use of increasingly scarce health resources.
منابع مشابه
بررسی میزان اثربخشی توپیرامات در بهبود سردردهای میگرنی
Abstract Background: Several studies suggest improvements in quality of life in migraine patients with topiramate. MIDAS (Migraine Disability Assessment) and HIT6 (Headache Impact Test) are two questionnaires for evaluating migraine severity. The aim of this study was to assess the efficacy of Topiramate 100 mg/day in control and prophylaxis of migraine headache. Materials and methods: Eigh...
متن کاملTopiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
Migraine is a very common disorder characterized by the combination of typical headache with associated autonomic symptoms and/or the presence of aura. Considerable advances have been made in recent years to understand the pathophysiology of migraine, which has led to improved treatment options for the acute migraine attack as well as migraine prophylaxis. Unfortunately, preventive treatment is...
متن کاملTopiramate for migraine prevention: an update.
Although the drug topiramate initially was developed for the treatment of epilepsy and received its first US Food and Drug Administration (FDA) approval for that purpose, it subsequently was shown to be effective for the prevention of migraine headaches and is FDA approved for that indication as well. Migraine and epilepsy share a considerable number of biologic and clinical features, and it fo...
متن کاملEvidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society.
OBJECTIVE To provide updated evidence-based recommendations for the preventive treatment of migraine headache. The clinical question addressed was: What pharmacologic therapies are proven effective for migraine prevention? METHODS The authors analyzed published studies from June 1999 to May 2009 using a structured review process to classify the evidence relative to the efficacy of various med...
متن کاملTopiramate: Safety and Efficacy of its Use in the Prevention and Treatment of Migraine
Migraine headaches are typically episodic in nature and may affect nearly 10% of the population. In addition to treatment, prevention of subsequent episodes or progression to a chronic migraine state is an important therapeutic area. Topiramate is a centrally acting medication approved for both the prevention of seizures and migraine headache. At this time, the exact mechanism of how topiramate...
متن کامل